The Effect of Multiple Sclerosis (MS) on Central Nervous System (CNS)


Dear Editor,

Multiple sclerosis (MS) is an autoimmune disorder of the CNS in which myelin components are specifically targeted by the immune system and lead to the destruction of myelin axons and associated debilitating symptoms [1-3]. Also, according to studies, no effective treatment for this disease has been found. Therefore, a safe and effective treatment option for MS is needed. Also, the central nervous system (CNS) is separated from the immune system by a blood-brain barrier and is traditionally considered “immune system protection”, and immune cells are also able to target the brain and lead to CNS autoimmune disorders Pahan et al. [4]. An article measuring the effects of cinnamon on MS mice used cinnamon and the brown bark of the cinnamon tree, which has been used as a spice or flavoring around the world for centuries. In addition, medieval physicians used cinnamon for medical purposes to treat a variety of disorders such as osteoarthritis, cough, hoarseness, sore throat, etc. Also, according to the findings of various articles, the results show that widespread inflammation, Loss of regulatory T cells (Tregs), autoimmune Th1 and Th17 cell hyperactivity, failure of the cerebral blood-brain barrier (BBB) and blood-spinal cord barrier (BSB), and loss of light-protective molecules in the CNS are some of the symptoms that Demystifying manifestations are required in MS [1-3]. Interestingly, NaB treatment is able to inhibit the expression of proinflammatory molecules in cultured astrocytes and microglia [4]. Reversal of NaB by inhibiting NF-κB activation and expression of nitric oxide synthase (iNOS) by mevalonate, 3-hydroxy-3- methylglutaryl-coenzyme A and farnesyl pyrophosphate, mediators of the mevalonate pathway, in active astrocytes suggests that NaB. It has an inflammatory effect by inhibiting the cholesterolbiosynthesis pathway However, although NaB is able to lower cholesterol levels, cholesterol has no role in inhibiting NaBmediated iNOS [4]. Also, in an article by Brahmachari et al. [4], they measured the effects of cinnamon on mice with MS in which NaB reduced NF-κB activation and iNOS expression in glial cells by reducing p21ras activation, according to which oral administration of cinnamon powder [5] and drinking water containing NaB metabolite [4] suppresses iNOS and IL-1β expression in vivo in the spinal cord and cerebellum of EAE mice, these findings suggest that cinnamon is able to reduce in vivo inflammation in rat CNS EAE is also another feature of neurodegenerative disorders such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), cinnamon and NaB. It also improves hippocampal function in an animal model of AD [6] and from nigrostriatum. Animal model PD Protects [7].


  1. Chen BY, Chiara G, Brendon V, Andrew Q, Caius GR, et al. (2020) 18F-FAC PET visualizes brain-infiltrating leukocytes in a mouse model of multiple sclerosis. Journal of Nuclear Medicine 61(5): 757-763.
  2. Steinman L (1996) Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system. Cell 85(3): 299-302.
  3. Mondal S, Madhuchhanda K, Malabendu J, Avik R, Suresh BR, et al. (2020) IL-12 p40 monomer is different from other IL-12 family members to selectively inhibit IL-12Rβ1 internalization and suppress EAE. Proceedings of the National Academy of Sciences 117(35): 21557-21567.
  4. Brahmachari S, Jana A, Pahan K (2009) Sodium benzoate, a metabolite of cinnamon and a food additive, reduces microglial and astroglia inflammatory responses. J Immunol 183(9): 5917-5927.
  5. Mondal S, Pahan K (2015) Cinnamon ameliorates experimental allergic encephalomyelitis in mice via regulatory T cells: Implications for multiple sclerosis therapy. PLoS One 10(1): e0116566.
  6. Modi KK, Avik R, Saurabh B, Suresh BR, Kalipada P (2015) Cinnamon and its metabolite sodium benzoate attenuate the activation of p21rac and protect memory and learning in an animal model of Alzheimer’s disease. PLoS One 10(6): e0130398.
  7. Khasnavis S, Pahan K (2014) Cinnamon treatment upregulates neuroprotective proteins Parkin and DJ-1 and protects dopaminergic neurons in a mouse model of Parkinson’s disease. J Neuroimmune Pharmacol 9(4): 569-581.

Article Type

Letter to Editor

Publication history

Received Date: November 02, 2021
Published: December 08, 2021

Address for correspondence

Ali Ahmadi, Student, Student Research of Medical Committee, Department of Medical Sciences, Islamic Azad University Sari Branch, Iran


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How to cite this article

Ali A. The Effect of Multiple Sclerosis (MS) on Central Nervous System (CNS). 2021- 3(6) OAJBS.ID.000358.

Author Info

Ali Ahmadi*

Department of Medical Sciences, Islamic Azad University Sari Branch, Iran