Better Outcomes in High-Power Short-Duration Compared to Low-Power Long-Duration Atrial Fibrillation Ablation in One-Year Follow-Up


Introduction: Different results are described after atrial fibrillation ablation and multiples predictors of recurrence are well established. Objective: Evaluate and analyze if patients submitted to first time atrial fibrillation (AF) ablation with high-power short-duration (HPSD) have better outcomes compared to low-power long-duration (LPLD). Methods: Observational, retrospective study, 144 patients submitted to HPSD and LPLD ablation. HPSD: 71 patients, 50(70.42%) males, mean age 59.73 years, 52(73.24%) hypertension, 44(61.97%) obstructive apnea, 23(32.39%) arterial disease, 20(28.17%) Diabetes, and 10(14.08%) strokes. CHADS2VASC2 2.57. CT: 73 patients, 50(68.49%) males, mean age 60.7 years, 53(72.60%) hypertension, 41(56.16%) obstructive apnea, 28(38.36%) arterial disease, 14(19.17%) Diabetes and 8 (10.96%) strokes. CHAD2SVASC2 2.22. Results: Recurrence occurred in 33 patients (22.92%) at 12 months follow-up, of these, HPSD with 9 patients and LPLD with 24 patients. At the end of study 62 (87.32%) of 71 HPSD patients were in sinus rhythm comparing to 49 (67.12%) of 73 patients in LPLD (P of .0039). Conclusion: HPSD compared to LPLD showed a superiority in maintaining sinus rhythm at 12 months and a significant lower recurrence rate. Also, lower procedure time, esophageal heating and radiofrequency time was significant lower in HPSD technique.


Atrial fibrillation; Atrial tachyarrhythmias; Recurrence rate; First-pass isolation; Atrial fibrillation ablation


More than two decades ago; Haïssaguerre and his collaborators [1] concluded that ectopic beats from pulmonary veins were atrial fibrillation (AF) triggers and showed that ablation can be a treatment for these triggers. Since then, the electrophysiology community has discovered factors that limit the success of this procedure in conventional supraventricular tachycardias [2,3]. For example, as a central objective of the treatment interventions for AF; the left atrial anatomy and its surrounding organs are a limiting factor during pulmonary vein isolation (PVI) [4-7]. In addition to the anatomical limitations, questions have been raised regarding the biophysics of lesions induced by radiofrequency [8,9]. One of the solutions for these limitations and for the achievement of better results is the adoption of new technologies; such as irrigated catheters and; more recently; catheters containing sensors that measure real time contact force [10-14] using higher power settings in the radiofrequency generators associated with short applications times.


The objective of the present study was to define if there is better outcome in the long-term success rate with the maintenance of sinus rhythm in patients after atrial fibrillation ablation with highpower short-duration (HPSD) compared to patients submitted to conventional ablation; with low-power long-duration (LPLD).


Study Population

We performed 144 consecutive first catheter atrial fibrillation ablations with the LPLD and HPSD technique. This post-hoc analysis was performed with the last patients submitted to LPLD and the first one with HPSD; and data were collected between January 2016 and January 2019. Patients were divided in two groups; patients using HPSD and patients submitted to LPLD ablation (Table 1).

Among the 71 HPSD patients; with mean age of 59.73 years; among them; 50 (70.42%) were males; 52 (73.24%) hypertension; 44 (61.97%) obstructive sleep apnea; 23 (32.39%) arterial disease; 20 (28.17%) diabetes; and 10 (14.08%) strokes. Mean CHADS2VASC2 2.57 (0-8). Mean left atrial diameter of 40.40mm (33-62); paroxysmal AF in 39 (54.93%) patients and the mean time from diagnosis to catheter ablation was 23 (4 to 144) months.

Among the 73 LPLD patients; with mean age of 60.7 years; among them; 50 (68.49%) were males 53 (72.60%) hypertension; 41 (56.16%) obstructive sleep apnea; 28 (38.36%) arterial disease; 14 (19.17%) diabetes and 8 (10.96%) strokes. Mean CHADS2VASC2 2.22 (0-7). Mean left atrium diameter of paroxysmal AF in 52 (71.23%) and the mean time for AF diagnosis to ablation was in Group A and 25.63 (3-144) months.

Pre-Ablation Investigation for Thrombus Exclusion

Patients underwent a transesophageal echocardiogram (TEE) and/or angiotomography of the left atrium and pulmonary veins prior to the procedure. Both exams for exclusion of the thrombus; diameter of the left atrium; and other measurements was performed on the day of the procedure or up to 48 hours before ablation.

Catheter Ablation

All patients underwent ablation using an uninterrupted oral anticoagulation protocol (OAC). Patients also had their antiarrhythmic drugs suspended for 5 half-lives prior to the procedure; with the exception of amiodarone; which was maintained for the procedure. The main objective was to isolate the antral portion of the pulmonary veins [2,15]. In cases of patients with previously diagnosed atrial flutter; the tachyarrhythmia was also ablated at the end of the PVI; time for this ablation and radiofrequency were not included in the data. Procedures were performed in sinus rhythm; and patients who were in atrial fibrillation or flutter underwent electrical cardioversion immediately before the ablation. For all patients, the EnSite Velocity mapping system version 5.0 was used with a TactiCath™ contact force sensing catheter; Agilis™ deflectable sheath; Viewflex™ intracardiac echocardiography probe; and Ampere™ radio frequency generator (St Jude Medical-USA / Abbott-USA).

In the HPSD ablation technique; in the posterior wall; atrial roof; and atrial flutter (if indicated); we set the power of radiofrequency generator to 45 Watts for no more than 6 seconds. On the anterior wall, we increased the power to 50 Watts with an estimated pressure of 10-20 grams of contact force for short periods of time [16]. The irrigation pump was always programmed for 35ml/min regardless of the power setting. For LPLD; the RF applications lasted no more than 30 seconds; we use an irrigation set of 17ml/min for pump flow; a contact force between 10 to 30 grams and applied 20 Watts in the posterior wall and 30 Watts elsewhere including in the cases of atrial flutter. At the end of the procedure, all patients were given a challenge of 12mg of adenosine for each antrum of the pulmonary veins in order to unmask any dormant veins and assess the need for re-ablation of their reconnection [17,18].

In addition to analyzing the real-time contact force values across all radiofrequency applications; we evaluated the impedance measurements in the EP recording system looking for gradual falls that might indicate lesion formation [8-11]. We used a dragging technique for catheter ablation (CA) and made all efforts to avoid catheter jumps. If a catheter jump did occur; the radiofrequency application was immediately interrupted; and we returned to the spot before the jump to continue the ablation [19-23]. We did not use other features provided by the contact force catheter, such as the lesion index (LSI) and force-time integral (FTI) [24]. All patients received esophageal temperature monitoring as described previously [25].


All patients signed the informed consent form according to the standards of ours Institutions, which follows national and international standards [26,27]. The study was approved by the Research Ethics Committee of the Institution.

Post-Ablation Follow-Up Protocol

Patients who were more than 75 years old or had multiple comorbidities remained in the intensive care unit after ablation for one day; those without these characteristics stayed at an apartment and were discharged from the hospital on the day after only if clinical evaluation; vascular punctures; chest X-ray; and electrocardiogram (ECG) were normal. Patients received a prescription of Sucralfate for 2g per day and Pantoprazole for 40mg twice daily for 4 weeks after the procedure. Same antiarrhythmic drugs were reintroduced after the procedure. Antiarrhythmics were maintained for 60 days and then suspended. Anticoagulants were interrupted at this time for patients with a CHADS2VASC2 score less than or equal to 328; except for patients who had a previous stroke and/or were 75 years old or more. In cases of atrial arrhythmia, amiodarone was the drug of choice to reestablish the normal sinus rhythm. If this approach was successful; the drug was used for 30 more days and then suspended. Direct current cardioversion (DC) was done in patients after the amiodarone challenge or if they achieved day 60th with atrial tachyarrhythmias. All patients were evaluated after 7 days; 1; 2; 3; 6; and 12 months with a medical appointment and ECG. After 3; 6; and 12 months; they also underwent 24 hours of Holter monitoring.


All tests were performed using BioStat statistical software (AnalystSoft Walnut; CA; USA). Continuous variables were expressed as mean-standard deviation. A result was considered significant if P value of < .05. The continuous variables were compared using the qui-square test were also used.


In the 12 months analysis; 62 (87.32%) of 71 HPSD patients were in sinus rhythm comparing to 49 (67.12%) of 73 patients in LPLD; demonstrating a significant P value of .0039; showing that when treated with the first approach patients had better outcomes with a much lower rate of recurrences (Figure 1). Of the 9 recurrent patients in HPSD ablation 6 (66.67%) were in AF and 3 (33.33%) in atypical atrial flutter/tachycardia; while in the LPLD patients 17 (70.83%) were in AF and only 7 (29.17%) in regular tachyarrhythmias; with non-significant P values (Table 2). In our study we only evaluate patients in first time ablation and a redo procedure was not performed in this group of patients.

Making more data analysis of other findings of this study we observed some differences in the results between the two techniques: (1) lower rate of esophageal heating in HPSD with 34 of 71 patients showing elevation in esophageal temperature in comparison to 52 of 73 patients in LPLD with a significant P-value of .0019; (2) equal left atrium time between the techniques; with a P value of.0839; (3) lower total ablation time; with 94.54 minutes in HPSD and 113.55 minutes in LPLD achieving a significant P-value of .0059; (4) a major difference in the radiofrequency time (RF); with HPSD protocol showing 1964.84 seconds and LPLD with 5017.80 seconds; and a remarkable P-value of <0.00001(Table 3). Another interesting finding of our date was a small number of reconnections spontaneously or after a challenge of 12mg of Adenosine. In this series of patients; HPSD ablation showed a total of 4 (5.63%) left PVs reconnections and 3 (4.23%) in right PVs and LPLD ablation; 5 (6.85%) in left PVs and 3 (4.11%) in right PVs; with a nonsignificant P-value.


In this retrospective; observational study; we observed a high rate of sinus rhythm at 12 months follow-up in patients submitted to HPSD compared to those submitted to LPLD ablation. In our first report16 comparing these two techniques last year; in 76 patients we do not saw a clear benefit in terms of better outcome in maintenance of sinus rhythm comparing the two groups. With a recurrence rate of 17.07% in the HPSD group and 31.42% in LPLD the P value was .14 but we observed that this could be a bias and if we follow these patients for a longer time or compare a higher number of patients in both groups result could be distinct favoring a better outcome for HPSD patients [28].

The first report from our knowledge was that from Bunch et al. [29] also comparing the results for long term outcome; with 3 years of follow-up; showed no superiority of the HPSD ablation compared to the LPLD approach. The major difference between both studies was that in all of our patients the ablation was performed with a contact force sensing catheter and this was not observed in their patients. Since this; we try to perform a study including only patients submitted to AF ablation with contact force sensing catheters; which is the subject of this manuscript.

As in another series of cases we had a small number of reconnections spontaneously or after a challenge of 12mg of Adenosine. In our series; in HPSD ablation we had a total of 4 (5.63%) left PVs reconnections and 3 (4.23%) in right PVs and in LPLD ablation 5 (6.85%) in left PVs and 3 (4.11%) in right PVs; with a non-significant P value. In the paper of Kamatsu et al. [30] that in 20 patients submitted to HPSD ablation they had no cases of reconnection; and in the paper by Berte et al. [31]; the rate of reconnections in two different groups with different approaches varied from 21 to 33%. In these two studies using HPSD ablation the rate of PVs reconnections varied from 33 to 0% showing a huge variation in this type of technique.

As a matter of additional information, 4 HPSD patients went back to the electrophysiology lab for a redo procedure since they had symptomatic tachyarrhythmias that failed to medical therapy; 2 patients were in AF and 2 in atypical atrial flutter. The electrophysiologic findings was 3 patients without PVs reconnection and 1 patient with the left PVs reconnected. Of the LPLD patients, 16 of the 24 recurrent patients were submitted to a redo procedure with 11 showing AF and 5 atypical atrial flutters. Of these 16; in 12 patients at least 1 PV was reconnected and in the other 4 patients we did not document any PV reconnection; with the ablation procedure directed to treat left atrial flutters. Our results suggest; in a retrospective analysis of theses 144 patients; that patients submitted to HPSD ablation had at 12 months 87.32% of patients in sinus rhythm; while in LPLD only 67.12%.


This was a retrospective; observational; small sampled size study that practiced non-continuous cardiac rhythm monitoring using ECGs and 24-hour Holter monitoring to document the recurrence of atrial tachyarrhythmias. A larger sample size or continuous monitoring may produce in future different findings.


This study showed a high success rate of sinus rhythm maintenance for HPSD compared to LPLD with significant lower recurrence rates for patients treated with the first technique. Besides this result patients in HPSD ablation had significant lower procedure times, lower esophageal heating and radiofrequency times.


For their dedication and effort in data collection and patience; we appreciate the dedication of Christiane Amaral and Vanessa Rodrigues from the administration staff and Edevaldo da Silva; Marcel Burguês; and Rafael Zeni from the biomedical team.


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Article Type

Research Article

Publication history

Received date: July 27, 2020
Published date: September 22, 2020

Address for correspondence

Fabricio Sarmento Vassallo MD, Electrophysiologist- Coordinator of Electrophysiology of Instituto de Cardiologia do Espírito Santo and Santa Casa de Misericórdia Hospital, Brazil


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How to cite this article

Fabricio V, Lucas Luis M, Eduardo S, Carlos L, Christiano C, al. et. Better Outcomes in High-Power Short-Duration Compared to Low-Power Long-Duration Atrial Fibrillation Ablation in One-Year Follow-Up. 2020 - 2(5) OAJBS.ID.000218.

Author Info

Fabricio Vassallo1,2,3*, Lucas Luis Meigre1, Eduardo Serpa1,2,3, Carlos Lovatto2,3, Christiano Cunha2,3, Hermes Carloni2,3, Aloyr Simoes2,3, Karla Meira1,2, Flávia Pezzin1,2, Orly Lacerda2, Walter Batista2, Alberto Nogueira2, Dalton Amaral2 and Dalbian Gasparini2

1Instituto de Cardiologia do Espírito Santo, Brazil
2Santa Rita de Cassia Hospital, Brazil
3Santa Casa de Misericórdia Hospital, Brazil

Figure 1: Types of atrial tachyarrhythmias recurrences at the top and the total recurrence rate at the bottom in HPSD and CT (LPLD) ablations.


Table 1: Clinical features.


Table 2: Recurrence characteristics at 12 Months in HPSD and CT (Conventional technique with low-power long duration) patients.


Table 3: Ablation features in HPSD and CT (Conventional technique with low-power long duration). NS= non-significant with P value of > .05.


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